The F-15C MSIP II is a further development of the F-15A, the F-15C being almost impossible to visually distinguish from its earlier predecessor. It was originally intended as a small upgrade to the F-15A, but would go on to be much more. Coming only a few years later, in its initial fit the only major difference was extra fuel, with the same engines, radar, and still no countermeasures. The Multi-Stage Improvement Program (MSIP) II refit in the mid-1980s aimed to rectify that. The F-15C gained access to the AN/APG-63 PSP radar, flares, new engines optimised for high speeds, and the ability to carry conformal fuel tanks to further extend range - all part of MSIP.

Soldiering on through the late '80s and '90s, the F-15C would gain access to the AIM-9M and AMRAAM before receiving two new radars in the early 2000s: the AESA AN/APG-63 (v)2 in late 2000, and the worse AN/APG-63 (v)1 in early 2001. The introduction of the AIM-9X and JHMCS in the early to mid-2000s led to more and more advanced variants of missiles and radars. The F-15C is still in service today, though it is finally in the process of being phased out by the F-15EX after almost five decades of service.

Introduced in Update "Seek & Destroy", the F-15C MSIP II in its mid-2000s variant serves as arguably one of the strongest air supremacy fighters in War Thunder. While its flight performance is marginally worse than the preceding F-15A, the F-15C stands out with its large complement of air-to-air missiles, notably sharing the crown for most ARH missiles at 8 with the F-15J(M) of the Japanese tree. HMD integration also provides the ability to slave both heat-seeking missiles and radar, which is a very useful capability in the fast-paced battles of 4th generation aircraft. The only real downside is the lacking CAS ability with only dumb bombs and 3 TV-guided bombs compared to many of the other fighters of this rank, as the F-15C wasn't intended as a multirole aircraft; that role was filled by the later F-15E Strike Eagle.