The He 111 H-16 was one of the many variants built from the He 111. At the beginning, He 111s were powered by Daimler-Benz engines, specifically the DB 600. However, the He 111 E introduced the Junkers Jumo 211 engine, which was a direct competitor to the DB 600. The main difference was the increase in power, but it was relatively the same as the DB 600. Many variants after the He 111 E continued to use the Jumo 211, but there were some exceptions that were powered by the DB 601.

The original He 111 H was fitted with the Junkers Jumo 211 A-1, which produced just under 1,000 hp. The H-16 mainly differed in having more armament and the Jumo 211 F-2 engines. The F-2 engines provided a significant power boost of around 34% compared to the original Jumo 211. Some of the armament changes included the addition of a 20 mm cannon in the nose as well as a 13 mm MG 131 machine gun. Other than the previously stated changes, it was largely the same as the other He 111 H variants.

The He 111 H-16 has been in the game since the start of the Open Beta Test prior to update 1.27. It is arguably the most powerful He 111 in-game due to its defensive armament updates and strong bomb load. Although it lacks the Fritz-X radio-controlled bomb found on the He 111 H-6, it has access to the SC2500 bomb, which is a 2,400 kg bomb with a 2,720 kg TNT equivalent warhead. The 20 mm MG FF/M cannon is mounted in the nose of the aircraft, which provides good defense against incoming threats. As for performance, although the H-16 received improved engines, it can very quickly overheat on WEP. Players should be wary of overusing WEP.