The Me 410 B variant was intended to improve on the Me 410 A with better engines. DB 603G engines were planned to be installed, but production and design issues meant the DB 603G would never be put into any aircraft. Thus, the Me 410 B was essentially just a Me 410 A but with more fuel, strengthened undercarriage, and an oxygen system for high-altitude flight. The Me 410 B-1 was designed quite early in the war, when the Luftwaffe was still utilizing the Me 410 as a high-speed bomber. Thus, it could still carry bombs and lacks the additional cannons of later variants. However, once the Luftwaffe realized the Me 410 was weak as a bomber, its purpose shifted towards converting the Me 410 B-1s in service to the Zerstörer standard. This usually resulted in more cannons being added.

The Me 410 B-1 has been in the game since the start of the Open Beta Test prior to Update 1.27. Since this is an early variant of the Me 410, it can still carry bombs and lacks modification sets like the WB 151A, which added two more MG 151s. Even by light bomber standards, the Me 410 B-1's loadout is fairly weak, with a maximum loadout of only two 500 kg bombs. One difference between the B-1 and A-1 is the replacement of the 7.92 mm machine guns with 13 mm machine guns. This slightly increases the firepower but still pales in comparison to something like the B-6/R3.