The Me 410 B-6/U3 was the naval variant of the Zerstӧrer. Its main mission was to escort German warships and vessels like the U-boat arm. For communication purposes, the FuG 200 “Zaunkӧnig” radio system was used to help talk to U-boats. In addition to the two MG 151 cannons, two MK 103 30 mm cannons were also fitted. Only a handful were actually produced so their impact was negligible; especially when the Germans lost France. Me 410 B-6s were then relegated to rescue missions and a few were found by the British.

The Me 410 B-6/R3 has been in the game since the start of the Open Beta Test prior to Update 1.27. It features a deadly set of cannon armament all mounted in the nose as well as two turrets for defensive purposes. With the armoured target belt, the MK 103 can easily penetrate through the engine decks of many tanks. It also retains the same armour and engines as the previous Me 410 variants. Unfortunately, this means the performance is still lacklustre and leaves Me 410 pilots vulnerable to enemy aircraft. Although it's armed with two 13 mm machine gun turrets, they have limited firing angles and enemy aircraft have to be in a very narrow position for both turrets to be utilized.