The USS Mitscher (DL-2/DDG-35) one of the experimental destroyers of the Mitscher class built for the United States Navy immediately after World War II. Originally designated DD-927, she was laid down on 3 October 1949 by the Bath Iron Works Corporation in Bath, Maine, then reclassified as a lead ship for a new destroyer class on 2 February 1951. The ship was named after Admiral Marc "Pete" Mitscher and was launched on January 26, 1952, by Mrs Marc A. Mitscher, Admiral Mitscher's widow, and commissioned on May 15, 1953. Between 18 March 1966 and 29 June 1968, she was modified to a guided missile destroyer and designated DDG-35, serving until 1978. On 1 June 1978, the USS Mitscher was decommissioned and struck from the Naval Vessel Register, and it was scrapped in July 1980.

Introduced in Update "Ground Breaking", the USS Mitscher is a unique destroyer with fewer gun platforms than prior destroyers but increased lethality. The two 127 mm/54 Mark 18 guns are positioned in a single turret in the bow and stern. The main turrets may be fully traversed, providing excellent coverage. While the ship has only two main guns, which severely limits its burst damage and accuracy when compared to other 127 mm guns, these weaknesses are offset by an extremely fast rate of fire of 40 shells per minute, allowing the USS Mitscher to deal a similar continuous damage output as other destroyers in her rank. Furthermore, the shells fired by the USS Mitscher are heavier and more potent in terms of penetration and explosive content than 127 mm shells from World War II. However, with only two gun mounts, its efficacy is severely hindered if one of these turrets is disabled.