In 1985, a BO 105 CB with tail number S-422 and registration D-HDMU was modernised to participate in the Swedish army's competition for a new anti-tank helicopter. The machine was equipped with a BGM-71 TOW anti-tank missile system, as well as new optics, receiving the designation BO 105 CB-2. After successfully passing the tests, the helicopter returned to Germany, and Sweden created their own version, the HKP9A.

The BO 105 CB-2 was introduced as a premium pack in Update 1.83 "Masters of the Sea". Like all aircraft in the BO 105 family, it boasts excellent manoeuvrability, allowing it to easily take advantage of various terrain features to launch ATGMs from unexpected directions, then quickly withdraw under the cover of the surrounding terrain. It can carry up to eight decent ATGMs with reasonable range, and is also able to equip countermeasures, allowing the BO 105 CB-2 to defend against IR missiles and some SPAA radars. However, the lack of armour protection means that the helicopter is extremely vulnerable to enemy aircraft and anti-aircraft fire.

The BO 105 CB-2 was removed from sale after the 2019 New Year sale. It has since been made available for purchase with Golden Eagles during the 2023 and 2024 "First Flight of the Bo 105" flash sales.