The Isuzu-class, JDS Isuzu (DE-211) (いすず, namesake: Isuzu River) was the lead ship of a series of four destroyer escorts for the JMSDF. The development of the Isuzu-class emerged following the initial reliance on a vast number of loaned vessels at the inception of the JMSDF. While there was a domestic focus on constructing Type A Patrol Ships (DD), the construction of Type B Patrol Ships (DE) was neglected. However, the need for replacement vessels became apparent as older ships were scheduled for retirement. This led to a shift in plans, resulting in the construction of new Type B Patrol Ships under the 1959 plan. During her service, Isuzu was primarily used to patrol Japanese coastal waters. The ship was withdrawn from the fleet in 1988, but it remained in service as the auxiliary vessel JDS Isuzu (ASU-7015). She was finally decommissioned in 1995.

Isuzu was introduced into the game in Update 1.95 "Northern Wind". The primary weapon on the Isuzu consists of four 3-inch Mk.33 automatic cannons in twin installations, capable of firing HE, HE-VT, or APHE shells. This configuration allows it to engage any target with a rapid-fire rate at mid-to-short range. Additionally, she is equipped with torpedoes and uniquely features a Mark 108 Weapon Alfa launcher. This launcher fires a RUR-4 anti-submarine rocket with an explosive mass of 113 kg of TNT at a velocity of 306 m/s, although it is limited to only 800 metres, relegating it to a close-range or last-resort weapon. As Isuzu is equipped only with her main guns and anti-submarine equipment, anti-aircraft duty is left to the manual fire of the main guns, preferably using HE-VT shells.