The P-51C/F-6C was a giant improvement over previous Mustangs. It had finally begun a new era of Mustangs that would be powered by the Merlin engine. The idea was spurred on in 1942, and P-51 Mustang airframes were shortly redesigned to fit the new engine. The airframe was strengthened, and certain control surfaces were changed. Merlin-powered P-51Cs would be one of the best-performing aircraft of their time, rivaling German aircraft like the Fw 190 and Bf 109. It was also a big improvement over the Allison-powered Mustangs, which lacked significant high-altitude performance. Due to the power increase, the P-51Cs also had their suspended armament weight limit increased, and more fuel tanks were added. A big 246-litre (65-gal) tank sat behind the pilot to increase the range. The F-6C was essentially a P-51C with two cameras for reconnaissance duties. The aircraft was quite popular and soon saw service with France, who conducted recon missions over Germany late in the war.

The F-6C-10-NA was introduced during Update "Wind of Change" as a vehicle reward for Battle Pass: Season VII, "Armoured Elephant". The main difference between the F-6C and previous Mustangs is its performance. The Packard-Merlin engine breathed new life into the Mustang due to its superior power at many altitudes. It was much faster and could climb far better. However, it retains the same armament as previous Mustangs, with four 12.7 mm machine guns mounted in the wings. Since the F-6 was intended for photo-reconnaissance duties, it lacks any provisions for suspended armament. The redesigned canopy also provides more visibility and more room. Much like many other P-51s, the F-6C excels in boom and zoom tactics, and players should not engage in dogfights unless it is absolutely necessary.