The Reggiane Re.2001 gruppo 22 is one of Re.2001s belonging to the 22º Gruppo autonomo caccia terrestre. Founded on 5 July 1918 with 181° Squadriglia and 182° Squadriglia equipped with Caproni Ca.40s, the 22° Gruppo took part in World War I. In the Second World War, it fought on the Eastern Front and in the naval air war in the Mediterranean where it received the first Re.2001s, and after the end of World War II was renamed the Gruppo Intercettori and integrated into the 51° Stormo.

The Re.2001 gruppo 22 is the premium version of the Re.2001 serie 1 introduced with the Update "Starfighters". The aircraft is very nimble, though it lacks exceptional speed. However, the combat flaps can enhance its manoeuvrability further, albeit at a significant cost in terms of speed. For sufficient power generation, WEP must be used, but not for too long, as insufficient cooling tends to overheat the engine and can damage it. The armament, consisting of two 12.7 mm and two 7.7 mm machine guns, can inflict great damage on the enemy if used skilfully.